Graduate Faculty of Interdisciplinary Research Faculty of Medicine
Clinical Medicine Science (Internal Medicine 2)


Kugiyama Kiyotaka


  1. 山梨医科大学教授(内科学第2) 2001/09/01
  2. 山梨大学教授(内科学講座第2教室) 2002/10/01

Academic degrees

  1. M.D., Ph.D. 1988/03

Research Areas

  1. 循環器内科学 Pathophysiology of ischemic heart disease, Diagnosis and treatment of heart failure, Pathophysiology of arteriosclerosis

Subject of research

  1. ホスホリパーゼA2受容体の解析による心血管病の成因解明と新規治療薬の開発

Proposed theme of joint or funded research

  1. PLA2メタボロームによる疾患脂質代謝マップの創成とその医療展開に向けての基盤構築


  1. Research paper (scientific journal) Joint High levels of stromal cell-derived factor-1α predict short-term progression of renal dysfunction in patients with coronary artery disease. Uematsu M, Nakamura T, Yoshizaki T, Watanabe Y, Deyama J, Watanabe K, Kobayashi T, Fujioka D, Saito Y, Nakamura K, Kawabata K, Obata JE, Kugiyama K. Clinical and Experimental Nephrology 2019/03/04 1342-1751 10.1007/s10157-019-01722-9
  2. Research paper (scientific journal) Joint Pulmonary vascular resistance is associated with brachial-ankle pulse wave velocity and adverse clinical outcomes in patients with heart failure with preserved ejection fraction Nakamura T, Uematsu M, Deyama J, Watanabe Y, Nakamura K, Kobayashi T, Saito Y, Fujioka D, Kawabata KI, Obata JE, Kugiyama K JOURNAL OF CARDIAC FAILURE 2019/02/27 1071-9164 10.1016/j.cardfail.2019.02.0192018
  3. Research paper (scientific journal) Joint Human soluble phospholipase A(2) receptor is an inhibitor of the integrin-mediated cell migratory response to collagen-I. Watanabe K, Watanabe K, Watanabe Y, Fujioka D, Nakamura T, Nakamura K, Obata JE, Kugiyama K AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 315/ 3, C398-C408 2018/09/01 0363-6143 10.1152/ajpcell.00239.2017
  4. Doctoral Thesis Joint Angiotensin II receptor blockers suppress the release of stromal cell-derived factor-1α from infarcted myocardium in patients with acute myocardial infarction Yoshizaki T, Uematsu M, Obata JE, Nakamura T, Fujioka D, Watanabe K, Nakamura K, Kugiyama K Journal of Cardiology 71/ 4, 367-374 2018/04 0914-5087 10.1016/j.jjcc.2017.10.002.
  5. Thesis(Others) Only Effect of coronary artery spasm on long-term outcomes in survivors of acute myocardial infarction. Deyama J, Nakamura T, Saito Y, Obata JE, Fujioka D, Nakamura K, Watanabe K, Kugiyama K. INTERNATIONAL JOURNAL OF CARDIOLOGY 257, 7-11 2018/04/15 0167-5273 10.1016/j.ijcard.2017.08.002

Research presentations

  1. Oral presentation(general) Pulmonary Vascular Resistance is Associated with Pulse Wave Velocity and Adverse Clinical Outcomes in Heart Failure with Preserved Ejection Fraction The 83st Annual Scientific Meeting of the Japanese Circulation Society 2019/03/29
  2. Oral presentation(general) Remnant Lipoproteinemia as a Mediator of Relationship between LDL-lowering and Improvement of Endothelial Dysfunction in Patients with Coronary Artery Disease The 83st Annual Scientific Meeting of the Japanese Circulation Society 2019/03/29
  3. Oral presentation(general) ARB Suppress the Release of SDF-1α from Infarcted Myocardium in Survivors of AMI The 83st Annual Scientific Meeting of the Japanese Circulation Society 2019/03/29
  4. Oral presentation(general) S-glutathionylation, One of the Oxidative Protein Modification, Stimulate Adipogenesis and Obesity by Stabilizing C/EBP Beta The 83st Annual Scientific Meeting of the Japanese Circulation Society 2019/03/29
  5. Poster presentation Angiotensin II Receptor Blockers Suppress the Release of Stromal Cell-Derived Factor-1 Alpha From Infarcted Myocardium in Survivors of Acute Myocardial Infarction American Heart Association Scientific Sessions 2018 2018/11/10

Joint research with off-campus or faculty, etc. outside of the organization

  1. 2014/10/01-2019/03/31 公益財団法人東京都医学総合研究所 Sharing PLA2メタボロームによる疾患脂質代謝マップの創成とその医療展開に向けての基盤構築

Instruction results

  1. Achievement of hospital training physicians guidance 2018 20
  2. Doctoral dissertations guidance 2018 3
  3. Doctoral dissertations guidance 2017 4
  4. Achievement of hospital training physicians guidance 2017 20
  5. Doctoral dissertations guidance 2016 1

Social Contribution

  1. 山梨県メディカルコントロール協議会、 心臓部会委員長 2018/07/24-2018/07/24
  2. 山梨県メディカルコントロール協議会、 心臓部会委員長 2017/07/24-2017/07/24
  3. 山梨県メディカルコントロール協議会、 心臓部会委員長 2016/07/24-2016/07/24

Memberships of academic societies

  1. 米国心臓病学会
  2. 日本老年医学会
  3. 日本心血管インターベンション学会
  4. 日本心臓病学会
  5. 日本内科学会

Medical care in hospital activities, medical support, etc.

  1. Hospitalization 山梨大学医学部附属病院循環器、呼吸器科での入院患者対応 2001/09/01-2021/03/31
  2. Ambulatory care 山梨大学医学部附属病院での循環器内科外来 2001/09/01-2021/03/31