UNIVERSITY OF YAMANASHI
Graduate Faculty of Interdisciplinary Research Faculty of Medicine
Basic Science for Clinical Medicine (Molecular Pathology)

Professor

Fan Jianglin


Career

  1. 中国医科大学病理解剖学教室・助手 1986/08/01
  2. 佐賀医科大学日本文部省国費研究留学生 1987/01/17
  3. カリフォルニア大学サンフランシスコ校ポスドク研究員 1992/03/24
  4. 筑波大学基礎医学系・病理学・講師 1995/06/01
  5. 筑波大学大学院人間総合科学研究科病理学・助教授 2003/03/01
  6. 筑波大学先端学際領域研究センター生命情報機能研究アスペクトプロジェクト・リーダー 2003/04/01
  7. 山梨大学教授(大学院医学工学総合研究部・分子病理学講座) 2006/03/01
  8. 山梨大学教授(病理学講座第1教室) 2006/03/01
  9. 山梨大学教授(分子病理学講座) 2006/04/01

Academic background

  1. 1983/07/31

Academic degrees

  1. 医学士 1983/08/12
  2. 修士(医学) 1986/07
  3. Ph.D. 佐賀医科大学 1992/03/24
  4. 博士(医学) 1992/03/25

Research Areas

  1. 実験病理学 Molecular Pathology

Research keywords

  1. Translational Research
  2. Atherosclerosis,hypercholesterolemia, inflammation, transgenic rabbit models, diabetes, obesity, life-style-related disease, translational research, molecular pathology

Subject of research

  1. 動脈硬化・糖尿病・肥満の分子病態の解明 血管分子生物学 炎症 遺伝子改変ウサギモデルの開発及び応用
  2. Atherosclerosis Hyperlipidemia,diabetes, obesity Inflammation Development of genetically modified rabbits for the study of atherosclerosis Translational research
  3. Translational Research

Bibliography

  1. Fundamentals of Laboratory Animal Science Enqi Liu, Jianglin Fan CRC Press 2017/07/28 978-1-4987-4351-8
  2. C‐Reactive Protein and its Pathophysiological Roles in Atherosclerosis Jianglin Fan, Jifeng Zhang and Y. Eugene Chen - John Wiley & Sons Inc. 2015/03/27 978-1-118-28591-6
  3. Rabbit genomics, transgenesis, cloning and models Louis-Marie Houdebine, Jianglin Fan. - Springer Netherlands 2009/05/18 978-90-481-2227-1

Papers

  1. Research paper (scientific journal) Joint Hypoxic and Cold Adaptation Insights from the Himalayan Marmot Genome. Liang Bai, Baoning Liu, Changmian Ji, Sihai Zhao, Siyu Liu, Rong Wang, Weirong Wang, Pu Yao, Xuming Li, Xiaojun Fu, Haiyan Yu, Min Liu, Fengming Han, Ning Guan, Hui Liu, Dongyuan Liu, Yuanqing Tao, Zhongdong Wang, Shunsheng Yan, Greg Florant, Michael T. Butcher, Jifeng Zhang, Hongkun Zheng, Jianglin Fan and Enqi Liu. iScience Cell Press (Elsevier) 11, 519-530 2019/01/25 10.1016/j.isci.2018.11.034
  2. Research paper (scientific journal) Joint Hypertension Enhances Advanced Atherosclerosis and Induces Cardiac Death in Watanabe Heritable Hyperlipidemic Rabbits. Bo Ning, Yajie Chen, Ahmed Bilal Waqar, Haizhao Yan, Masashi Shiomi, Jifeng Zhang, Y. Eugene Chen, Yanli Wang, Hiroyuki Itabe, Jingyan Liang, Jianglin Fan. AMERICAN JOURNAL OF PATHOLOGY ELSEVIER 188/ 12, 2936-2947 2018/12 0002-9440 10.1016/j.ajpath.2018.08.007
  3. Research paper (scientific journal) Joint Genomic and Transcriptomic Analysis of Hypercholesterolemic Rabbits: Progress and Perspectives. Jianglin Fan, Yajie Chen, Haizhao Yan, Baoning Liu, Yanli Wang, Jifeng Zhang, Y. Eugene Chen, Enqi Liu and Jingyan Liang. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES MDPI 19/ 11 2018/11/08 1422-0067 10.3390/ijms19113512
  4. Research paper (scientific journal) Joint Salusin-α Inhibits Proliferation and Migration of Vascular Smooth Muscle Cell via Akt/mTOR Signaling. Shoucui Gao, Liran Xu, Yali Zhang, Qingqing Yu, Jiayan Li, Hua Guan, Xiaojing Wang, Daxin Cheng, Yi Liu, Liang Bai, Rong Wang, Jianglin Fan, Sihai Zhao, Enqi Liu. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY Karger 50/ 5, 1740-1753 2018/11/02 1015-8987 10.1159/000494792
  5. Research paper (scientific journal) Joint Spontaneous severe hypercholesterolemia and atherosclerosis lesions in rabbits with deficiency of low-density lipoprotein receptor (LDLR) on exon 7. Rui Lu, Tingting Yuan, Yingge Wang, Ting Zhang, Yuguo Yuan, Daijin Wu, Minya Zhou, Zhengyi He, Yaoyao Lu, Yajie Chen, Jianglin Fan, Jingyan Liang, Yong Cheng. EBioMedicine Elsevier 36, 29-38 2018/10 2352-3964 10.1016/j.ebiom.2018.09.020

Research presentations

  1. Oral presentation(general) Functional roles of MMPs in the pathogenesis of atherosclerosis. The 11th Asian and Pan-pacific Connective Tissue Societies Symposium & The 3rd National Conference of CSMB 2018/11/16
  2. Poster presentation Macrophage-derived MMP-9 enhances vascular calcification and progression of atherosclerosis in transgenic rabbits. XVIIIth International Symposium on Atherosclerosis 2018/06/09
  3. Oral presentation(invited, special) Can we treat atherosclerosis by stem cell therapy? 2018 Internatonal (Guangzhou) Stem Cell and Precision Medicine Industrialization Conference 2018/05/20
  4. Symposium workshop panel(nominated) 動脈硬化病理-known and unknown 第18回動脈硬化教育フォーラム 2018/02/04
  5. Poster presentation Macrophage-derived matrix metalloprotease-1 accelerates aortic aneurysm formation in transgenic rabbits. The 49th Annual Scientific Meeting of the Japan Atherosclerosis Society 2017/07/07

Prizes

  1. 第3回日本動脈硬化五島雄一郎学会賞 2008/07/11 動脈硬化の研究
  2. 日本病理学会学術研究賞 2006/11/23 遺伝子改変ウサギによる動脈硬化の分子病態の解明及びトランスレーショナルリサーチへの試み
  3. Irvine H. Page Arteriosclerosis Research Award(AHA) 2002/05/01
  4. 日本血管生物学会Young Investigator Award 1999/10/01
  5. 日本動脈硬化学会第7回学術奨励賞「最優秀賞」 1999/07/01

Joint research with off-campus or faculty, etc. outside of the organization

  1. 2010/06/15-2012/06/15 大塚製薬 Representative 高脂血症ウサギモデルを用いた創薬の研究 研究の総括と病理学解析
  2. 2008/05/27-2009/05/27 アストラゼネカ Representative 動脈硬化の発生における内皮リパーゼの役割
  3. 2007/03/20-2007/03/20 西安交通大学医学部 Representative 肥満ウサギモデルの開発
  4. 2007/03/20-2007/03/20 北京大学医学部 Representative Knock-down rabbits
  5. 2007/03/20-2007/03/20 Univeristy of Michigan Sharing Cardiovascular disease and CRP

Instruction results

  1. Achievement of student guidance 2017 6 5 3 3

Review of master's and doctoral thesis

  1. 2017 Chief examiner 2 2
  2. 2016 Chief examiner 2 2
  3. 2015 Chief examiner 1 1

Memberships of academic societies

  1. American Society for Biochemistry and Molecular Biology
  2. American Heart Association
  3. Japanese Association for Laboratory Animal Science
  4. The Japanese Circulation Society
  5. The Japanese Society of Pathology